Gregory MS<p><a href="https://gregory-ms.com/articles/300529/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300529" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300529</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300529</span></a></p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
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#MSChat
26 posts · 8 participants · 2 posts today
Gregory MS<p><a href="https://gregory-ms.com/articles/300498/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300498" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300498</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300498</span></a></p><p>MiR-342 is essential for Treg cells to mitigate autoimmune inflammation in central nervous system and allergic airway inflammation in the lung.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300423/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300423" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300423</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300423</span></a></p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300442/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300442" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300442</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300442</span></a></p><p>Liposomes loaded with the tolerogenic adjuvants all‐trans retinoic acid (RA) and vitamin D3 (VD3) are injected into the skin and selectively induce CD14+ dermal DC migration and CD1a dim DC migration. Migrated DCs from RA or VD3 liposome-injected skin differentiate into FoxP3+ CD127 low and ICOS+ Tregs.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300365/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300365" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300365</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300365</span></a></p><p>L2-a is a structurally optimized, highly selective BTKi designed to minimize drug-induced liver injury and improve blood-brain barrier permeability.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300367/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300367" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300367</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300367</span></a></p><p>Autologous hematopoietic stem cell transplantation (aHSCT) has been shown to benefit patients with relapsing and remitting multiple sclerosis (RRMS) who have an inadequate response to DMTs. A 56-year-old Filipino female with RRMS underwent aHSCT two years ago. She has not had any relapses, is not on any DMT, has a stable EDSS score of one,</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300368/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300368" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300368</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300368</span></a></p><p>Microglia play a critical role in central nervous system (CNS) pathologies including multiple sclerosis (MS). Their modulation offers therapeutic potential especially during progressive disease courses. Sipo modulated microglia populations, increasing CD163+ CD206+ and CX3CR1+ while reducing CD86+MHC-II+. cells. Proteomic spinal</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300373/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300373" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300373</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300373</span></a></p><p>Sheng Xuexiaoban capsules (SXXCs) restored immune dysfunction in ITP model mice. SXXCs treatment significantly improved the proportion and function of Tregs.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300375/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300375" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300375</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300375</span></a></p><p>with AM is effective in protecting nervous tissue against the demyelinating effects of lysophosphatidylcholine. SEM analysis reinforced the efficacy of AM.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300346/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300346" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300346</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300346</span></a></p><p>Multiple Sclerosis (MS) is the most common demyelinating disease of the Central Nervous System (CNS). Mediterranean, low-fat, ketogenic, or intermittent fasting diets might be beneficial to MS.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300321/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300321" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300321</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300321</span></a></p><p>The timing of myelination during development varies spatially according to the evolving functional demands of the maturing brain. Myelinating oligodendrocytes arise from the differentiation of oligodentrocyte precursor cells, a process that depends on the transcription factor Myrf. In this study, the inducible Myrf conditional knockout mouse model is used to characterize the impact of inhibitin...</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300332/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300332" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300332</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300332</span></a></p><p>Acthar Gel is an approved noncorticosteroid treatment for multiple sclerosis (MS) exacerbations. Melanocortin receptor 1 was expressed at substantially higher levels than the other MCR subtypes in human monocyte-derived macrophages and the only MCR gene detected in human adult microglia. The polarization of MDMs to a proinflammatory phenotype increased the expression and secretion of interleukin-</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300305/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300305" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300305</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300305</span></a></p><p>Myelination RegulAting oligodendrocyte associated LncRNA (MYRACL) is a regulator of functional maturation and oligodentrocytic myelination in human brain tissue. It is non-coding and conserved across species.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300309/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300309" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300309</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300309</span></a></p><p>There are no effective therapeutic options to promote the recovery of motor function following spinal cord injury (SCI). Ketogenic diet (KD) and quercetin (Que) were used to treat SCI in rats. The combined treatment significantly decreased cavity volume, reduced glial scarring and attenuated local inflammatory infiltration.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300215/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300215" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300215</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300215</span></a></p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300232/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300232" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300232</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300232</span></a></p><p>B cells play a critical role in the pathogenesis of autoimmune inflammatory diseases such as multiple sclerosis. Mice with B-cell-specific deletion of CRTH2 exhibit reduced numbers of IL-1β-producing B cells, resulting in amelioration of EAE.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300294/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300294" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300294</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300294</span></a></p><p>Demyelination is the underlying pathological mechanism of trigeminal neuralgia (TN). Ferroptosis has been implicated in neurodegenerative disorders associated with demyelination. The study has clarified the impact of ferroPTosis-induced demyselination in TN and provided a potential strategy for treating TN.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Bruno Amaral<p>The observatory page now loads faster and has a failsafe to make sure we load all <a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> medications, treatments, and topics. <a href="https://gregory-ms.com/observatory/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">gregory-ms.com/observatory/</span><span class="invisible"></span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>neurology</span></a> <a href="https://mastodon.social/tags/neurosky" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>neurosky</span></a> @gregory-ms.com</p>
Bruno Amaral<p>You may notice <span class="h-card" translate="no"><a href="https://mastodon.social/@gregory_ms" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>gregory_ms</span></a></span> posting less. This is because I increased the requirements to consider an article as relevant. We use 3 <a href="https://mastodon.social/tags/AI" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>AI</span></a> models that score each paper from 0 to 1, and now Gregory only posts the ones where the 3 give a score ≥ 0.9 <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/NeuroSky" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NeuroSky</span></a> <a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
Gregory MS<p><a href="https://gregory-ms.com/articles/300220/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300220" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">gregory-ms.com/articles/300220</span><span class="invisible">/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_300220</span></a></p><p>Gas6 is a promising therapy to promote remyelination in people with multiple sclerosis. Global genetic deletion of Gas6 or the Gas6 receptor Tyro3 results in reduced disease severity following induction of experimental immune encephalomyelitis in mice.</p><p><a href="https://mastodon.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://mastodon.social/tags/MSchat" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MSchat</span></a> <a href="https://mastodon.social/tags/MS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MS</span></a> <a href="https://mastodon.social/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a></p>
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