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#autoimmunity

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Public
Tom Kindlon

"Research finds potential “molecular mimics” behind #COVID -induced #autoimmune disease"

eurekalert.org/news-releases/1

“some of the human proteins the researchers identified as likely targets of COVID-induced #autoimmunity are only found in people with specific genetics”

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #Covidlonghaulers #PostCovidSyndrome @covid19 #Coronavirus
#COVID19 #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

News Release 26-Mar-2025 Research finds potential “molecular mimics” behind COVID-induced autoimmune disease Peer-Reviewed Publication University of Utah Health COVID infection has been linked to higher risk of autoimmune disorders, including rheumatoid arthritis and type 1 diabetes. But why the virus might cause the body’s immune system to go haywire remains unknown, making it difficult to develop therapies to avoid autoimmunity. One hypothesis is that viral “molecular mimics” that resemble the body’s own proteins trigger an immune response against the virus—and healthy tissues get caught in the crossfire.
Public
Thiago Carvalho

'To elucidate the in vivo function of neoself-antigens presented on MHC-II by decreased Ii expression, we analyzed the antigen specificity of clonally expanded autoreactive T cells in SLE patients as well as in drug-inducible Ii knockout (Ii-iKO) mice, which allowed us to delete the Ii from adult mice. We demonstrate that neoself-antigens presented on MHC-II upon decreases in Ii expression levels are recognized by CD4+ T cells as non-self-antigens and are the primary targets for autoreactive T cells clonally expanded in SLE patients. Furthermore, we suggested that EBV reactivation, which downregulates Ii expression, could be involved in the activation of neoself-reactive T cells.'
#Immunology #Autoimmunity
sciencedirect.com/science/arti

Public
Thiago Carvalho

'The T-cell engager teclistamab acts on T cells through CD3 (the defining marker of T cells) and targets plasmablasts and plasma cells through BCMA. Teclistamab has been shown to be highly effective in patients with multiple myeloma.4 Thus, we hypothesized that teclistamab may be effective for targeting severe autoimmune diseases, even after failure of conventional B-cell depletion.'
#Immunology #Immunotherapy #Autoimmunity
nejm.org/doi/full/10.1056/NEJM

Public
Charité Berlin

Impressive case at #CharitéBerlin: In a 23-year-old female patient with severe systemic #lupus erythematosus, the #AutoimmuneDisease is no longer detectable after treatment with a cancer medication. Only time will tell if the results will last, but the case marks the starting point for further studies.

👉 charite.de/en/service/press_re

Stand with blood samples, next to it small sample tubes into which a pipette transfers the blood. No more indications of systemic lupus can currently be found after the therapy with the bispecific antibody, either in the laboratory or clinically © Charité | Arne Sattler
#Medicine#Science#Research
Public
Chuck Darwin

When researchers gave healthy mice antibodies from patients with #Long #COVID, some of the animals began showing Long COVID symptoms
—specifically heightened pain sensitivity and dizziness.

It is among the first studies to offer enticing evidence for the #autoimmunity #hypothesis.

The research was led by #Akiko #Iwasaki, PhD, Sterling Professor of Immunobiology at Yale School of Medicine (YSM).

“We believe this is a big step forward in trying to understand and provide treatment to patients with this subset of Long COVID,” Iwasaki said.

Iwasaki zeroed in on autoimmunity in this study for several reasons.

First, Long COVID’s persistent nature suggested that a chronic triggering of the immune system might be at play.

Second, women between ages 30 and 50, who are most susceptible to autoimmune diseases, are also at a heightened risk for Long COVID.

Finally, some of Iwasaki’s previous research had detected heightened levels of antibodies in people infected with SARS-CoV-2.

yalemedicine.org/news/antibodi

Yale MedicineAntibodies From Long COVID Patients Provide Clues to Autoimmunity HypothesisPromising new research supports that autoimmunity—in which the immune system targets its own body—may contribute to Long COVID symptoms in some patients.
Public
Thiago Carvalho

'Twenty-nine different Car-T treatments for autoimmune diseases, ranging from the muscle inflammation condition myositis to multiple sclerosis, are now being tested in clinical trials by drugmakers including Novartis and Bristol Myers Squibb'

#Immunology #Autoimmunity #CARTcells

ft.com/content/a974f4c1-bb8a-4

www.ft.comCell therapy offers ‘single shot’ hope to autoimmune disease patientsUse of Car-T for lupus could drive surge in demand for a treatment that was first approved for blood cancers
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