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#epigenetics

4 posts4 participants1 post today
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ISOGG

“A stool sample, he explains, would contain DNA from colon tissue to help medical providers see evidence of mutations—the more mutations, the higher someone’s risk of colorectal cancer. Once you know someone is at high risk, you can take greater steps to monitor and catch the cancer early.” #dna #epigenetics #isogg #coloncancer #ecoli #colorectalcancer
news.yahoo.com/childhood-expos

Yahoo News · Childhood exposure to this bacteria could be driving rates of colorectal cancer in millennials and Gen Xers, new study warnsBy Ani Freedman
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ISOGG

“So what has to happen is that methyltransferase has to hit that site over and over and over again, and it gradually builds up methylation … and only with repeated hits from the methyltransferase do we build up enough methylation that the gene actually gets silenced.” #DNA #isogg #Epigenetics #methylation #geneadons
chemistryworld.com/news/epigen

Cellular DNA and epigenetics
Chemistry WorldEpigenetic editors enter clinical trialsNew wave of precision medicines amplify or silence genes, without altering genetic code
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ISOGG

When someone has a mutated version of both copies of their MAL genes, they end up with an AnWj-negative blood type, like the pregnant patient. Tilley and team identified three patients with the rare blood type that didn't have this mutation, suggesting that sometimes blood disorders can also cause the antigen to be suppressed. #bloodgroup #MAL #epigenetics #isogg #geneadons sciencealert.com/researchers-i

ScienceAlert · Researchers Identify New Blood Group After 50 Year MysteryWhen a pregnant woman had her blood sampled back in 1972, doctors discovered it was mysteriously missing a surface molecule found on all other known red blood cells at the time.
Public
ISOGG

“The primary goal was to investigate the genotoxicity of 32 commonly consumed food additives and six mixtures corresponding to dietary exposure in France. While our findings indicate the potential toxicity of some combinations, further research is needed to determine whether the in vitro concentrations used are predictive of a possible human health risks.” #DNA #ISOGG #epigenetics #foodadditives #geneadons
sciencedirect.com/science/arti

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ma𝕏pool

3rd method if inheritance besides DNA and RNA: Amyloid-like protein structures that have the ability to replicate making them possible inheritance vectors.

Noncanonical inheritance of phenotypic information by protein amyloids nature.com/articles/s41556-024

>we identify amyloid-like protein structures that are stably inherited in wild-type animals and influence traits. Their perturbation by genetic, environmental or pharmacological treatments leads to developmental phenotypes that can be epigenetically passed onto progeny.

NatureNoncanonical inheritance of phenotypic information by protein amyloids - Nature Cell BiologyEroglu et al. describe protein amyloid structures that are stably inherited across generations and transmit epigenetic memory in Caenorhabditis elegans. MSTR protein loss results in a transgenerational feminization phenotype through ectopic GLD-1 expression.
#biology#cellbiology#epigenetics
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