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8 posts3 participants3 posts today

**Tom Kindlon** @tomkindlon@disabled.social · 32m

Tom Kindlon @tomkindlon@disabled.social

"findings indicate even mild #COVID19 can result in persistent neurocognitive deficits,structural brain alterations, & functional network abnormalities,both in individuals with & without brain fog"

https://www.sciencedirect.com/science/article/abs/pii/S0010945225001017?via%3Dihub

Screenshot from Science for ME update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Cortex
Persistent neurocognitive deficits in long COVID: Evidence of structural changes and network abnormalities following mild infection — Samanci et al.
"findings indicate that even mild COVID-19 can result in persistent neurocognitive deficits, structural brain alterations, and functional network abnormalities, both in individuals with and without brain fog."

**Tom Kindlon** @tomkindlon@disabled.social · 39m

39m

Tom Kindlon @tomkindlon@disabled.social

From Germany:

Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia following SARS-CoV-2 infection in long COVID-19

https://link.springer.com/article/10.1007/s11306-025-02262-y

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

Metabolomics
Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia following SARS-CoV-2 infection in long COVID-19 — Bae et al.
"Our results demonstrate fluctuations in the lipoproteins in LC at some time points but become consistent from month from month 5 to month 20."

**Tom Kindlon** @tomkindlon@disabled.social · 45m

45m

Tom Kindlon @tomkindlon@disabled.social

From Spain

VEGFA Sex-Specific Signature is Associated to Long COVID Symptom Persistence

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5242670

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

Preprint: Lancet Group
VEGFA Sex-Specific Signature is Associated to Long COVID Symptom Persistence — Farré Ramon et al.
"This study provides novel insights into the pathophysiology of long COVID, uncovering significant immune dysregulation, vascular remodelling, and sex-specific differences." "These findings highlight critical mechanisms that may contribute to the long-term effects of the disease and suggest a need for sex-specific approaches in both diagnostics and treatment."

**Tom Kindlon** @tomkindlon@disabled.social · 12h

12h

Tom Kindlon @tomkindlon@disabled.social

Prolonged alterations in red blood cell rheology following mild SARS-CoV-2 infection: Implications for microvascular health

https://www.sciencedirect.com/science/article/abs/pii/S1521661625000865

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Clinical Immunology
Prolonged alterations in red blood cell rheology following mild SARS-CoV-2 infection: Implications for microvascular health — Pazara et al.
"This study demonstrates that mild SARS-CoV-2 infection can lead to persistent alterations in RBC rheology, marked by reduced deformability and increased aggregation. These changes likely contribute to microvascular dysfunction and may underlie symptoms associated with PACS. Notably, female participants exhibited more pronounced impairments, suggesting possible sex-specific effects."

**Tom Kindlon** @tomkindlon@disabled.social · 1d

Tom Kindlon @tomkindlon@disabled.social

From Italy:

Multicentre retrospective detection of nailfold videocapillaroscopy abnormalities in long covid patients

https://rmdopen.bmj.com/content/11/2/e005469

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

RMD Open
Multicentre retrospective detection of nailfold videocapillaroscopy abnormalities in long covid patients — Ginaldi et al.
"NVC shows significant microvascular damage in long covid (LC) patients compared with matched healthy controls. Dilated capillaries, microhaemorrhages, abnormal shapes and reduced capillary density are still detectable in LC patients 12 months after acute SARS-CoV-2 infection."

**Tom Kindlon** @tomkindlon@disabled.social · 1d

Tom Kindlon @tomkindlon@disabled.social

Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06535-x

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

Journal of Translational Medicine
Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries — Sardell et al.
"results demonstrate the reproducibility of long COVID disease signal found by combinatorial analysis, broadly validating the results of the original analysis. They provide compelling evidence for a much broader array of genetic associations with long COVID than previously identified through traditional GWAS studies."

**Tom Kindlon** @tomkindlon@disabled.social · 1d

Tom Kindlon @tomkindlon@disabled.social

From Germany:

"Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications"

https://www.mdpi.com/1422-0067/26/10/4562

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

International Journal of Molecular Sciences
Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications — Semo et al.
"Our findings reveal that CD14++ monocytes from these patients exhibit profound bioenergetic impairment, defective oxidative stress adaptation, elevated mitochondrial membrane potential, and region-specific mtDNA damage, offering mechanistic insights into the pathophysiology of PASC-related cardiovascular sequelae."

**Tom Kindlon** @tomkindlon@disabled.social · 2d

Tom Kindlon @tomkindlon@disabled.social

Richard Aubrey White provides a thorough critique of the study "Brief Outpatient Rehabilitation Program for Post-COVID-19 Condition"

https://www.forskersonen.no/covid19-kronikk-long-covid/lofterik-behandling-av-long-covid-uten-bevis/2503503
https://www.forskersonen.no/covid19-debattinnlegg-meninger/jeg-presenterer-ikke-var-studie-som-en-losning-pa-long-covid/2505218

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Norway In an opinion piece for the research news site Forskningno, Dr. Richard Aubrey White provides a thorough critique of the study "Brief Outpatient Rehabilitation Program for Post-COVID-19 Condition" by Nerli, Wyller et al. The study claims their treatment results are clinically significant, which White argues is misleading and shows how.
Senior doctor and lead author Tom Farmen Nerli claims in a reply that the study is so promising that their treatment should be offered to the patient group as there are no other documented effective treatments available.
White's opinion piece l Nerli's answer l

**Tom Kindlon** @tomkindlon@disabled.social · May 9

May 9

Tom Kindlon @tomkindlon@disabled.social

Mitigating fatigue in long COVID patients with MYPplus: a clinical observation

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-025-10984-6

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

BMC Infectious Diseases
Mitigating fatigue in long COVID patients with MYPplus: a clinical observation — Choi et al.
"This observational study aimed to evaluate the efficacy of MYPplus, an herbal formulation composed of Astragali Radix, Salviae Radix, and Aquilariae Lignum, in alleviating fatigue and brain fog in patients with Long COVID."

**Tom Kindlon** @tomkindlon@disabled.social · May 9

May 9

Tom Kindlon @tomkindlon@disabled.social

Risk of post-acute symptoms among adults: A comparison study of severe COVID-19, pneumonia, and influenza

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0322020

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

PLOS ONE
Risk of post-acute symptoms among adults: A comparison study of severe COVID-19, pneumonia, and influenza — Caroline M. Schaefer et al.
"Those with influenza were less likely than those with COVID-19 to experience post-acute symptoms while those with pneumonia were more likely to have post-acute illness than those with COVID-19."

**Tom Kindlon** @tomkindlon@disabled.social · May 9

May 9

Tom Kindlon @tomkindlon@disabled.social

Trajectories of persisting Covid- 19 symptoms up to 24 months after acute infection: findings from the Predi-Covid cohort study

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-025-11023-0

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

BMC Infectious Diseases
Trajectories of persisting Covid- 19 symptoms up to 24 months after acute infection: findings from the Predi-Covid cohort study — Fischer et al.
"We identified 2 total symptom score trajectories: T1 “Mild symptoms, fast resolution” (N = 376; 67.7%), and T2 “Elevated and persisting symptoms” (N = 179; 32.3%)."

**Tom Kindlon** @tomkindlon@disabled.social · May 9

May 9

Tom Kindlon @tomkindlon@disabled.social

From Sweden:

Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study

https://www.medrxiv.org/content/10.1101/2025.04.26.25326246v1

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Preprint: MedRxiv
Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study — Madlene Holmqvist et al.
"We analyzed the complement activation markers C3bc, C3bBbP and TCC in 48 PASC patients." "Although the patients with a mild SARS-CoV-2 infection had a trend towards more severe PASC, we could not find any significant differences in complement activation markers between these patients and controls."

**Tom Kindlon** @tomkindlon@disabled.social · May 8

May 8

Tom Kindlon @tomkindlon@disabled.social

From Brazil:

Acute and chronic post-COVID-19 conditions: A study of genetic integrity and clinical markers

https://www.sciencedirect.com/science/article/abs/pii/S1383571825000294

Screenshot is from the latest Science for ME weekly update

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Acute and chronic post-COVID-19 conditions: A study of genetic integrity and clinical markers — Martins et al.
"results suggest that genetic instability, as assessed by the comet assay, may not account for the clinical differences observed in post-COVID-19 syndrome" "The biochemical parameters analyzed in our study revealed important differences between the acute and chronic post-COVID groups, as well as between genders"

**Tom Kindlon** @tomkindlon@disabled.social · May 8

May 8

Tom Kindlon @tomkindlon@disabled.social

From Germany:

Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID

https://www.sciencedirect.com/science/article/pii/S1521661625000774

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Clinical Immunology
Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID — Renner et al.
"Long-COVID patients showed clear signs of T cell hyper-activation predominantly in the CD8+ T cell subset with a 4-fold higher expression of CD25 and 2-fold more effector-memory T cells. Following polyclonal T cell stimulation, we found a 2-fold stronger upregulation of CD25 and a 7-fold higher release of IL-3 in Long-COVID."

**Tom Kindlon** @tomkindlon@disabled.social · May 7

May 7

Tom Kindlon @tomkindlon@disabled.social

(US)
#MillionsMissing 2025: Sending Out An SOS

https://www.meaction.net/2025/04/02/millionsmissing-2025-sending-out-an-sos/

Screenshot from the AMMES May email newsletter

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

#MillionsMissing 2025: Sending Out An SOS
This #MillionsMissing, we are launching a campaign that is largely focused on the seismic cuts being made to research funding, healthcare, and disability services in the U.S.
We know that the state of U.S. research institutions will have a massive impact on whether we are able to advance research for myalgic encephalomyelitis (ME) and Long COVID over the next decade. This will impact everyone globally. We encourage you to join in the fight as we send an SOS to our governments to Save our Support Systems. Save our Science. Save Our Society!
Read more here>>

**Tom Kindlon** @tomkindlon@disabled.social · May 6

May 6

Tom Kindlon @tomkindlon@disabled.social

Important new research from the Netherlands:

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest

https://www.medrxiv.org/content/10.1101/2025.05.02.25326885v1

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers @covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Abstract
Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance of physical activity, resulting in a lower aerobic fitness, which may contribute to skeletal muscle abnormalities. Here, we compared whole-body exercise responses and skeletal muscle adaptations after strict 60-day bed rest in healthy people with those in patients with long COVID and ME/CFS, and healthy age- and sex-matched controls. Bed rest altered the respiratory and cardiovascular responses to (sub)maximal exercise, while patients exhibited respiratory alterations only at submaximal exercise. Bed rest caused muscle atrophy, and the reduced oxidative phosphorylation related to reductions in maximal oxygen uptake. Patients with long COVID and ME/CFS did not have muscle atrophy, but had less capillaries and a more glycolytic fibers, none of which were associated with maximal oxygen uptake. While the whole-body aerobic capacity is similar following bed rest compared to patients, the skeletal muscle characteristics differed, suggesting that physical inactivity alone does not explain the lower exercise capacity in long COVID and ME/CFS

**Tom Kindlon** @tomkindlon@disabled.social · May 5

May 5

Tom Kindlon @tomkindlon@disabled.social

Documentary: Doctors as Patients

https://youtu.be/J0ywwLIfH_w?si=hZv0mzlGtnLzpwim

Screenshot is from the latest Science for ME weekly update

Documentary Doctors as Patients
A moving, honest and thought provoking documentary interviewing five medical doctors with post-acute infection-associated syndromes like ME, Long Covid and chronic Lyme. They talk about their experiences, what they were taught about these illnesses as students and what they have learned as patients. Directed by Anil van der Zee. The documentary is in Dutch and has English subtitles.
Documentary l Thread

**Tom Kindlon** @tomkindlon@disabled.social · May 4

May 4

Tom Kindlon @tomkindlon@disabled.social

New from Systrom team (US):

Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID: Commonalities Detected by Invasive Cardiopulmonary Exercise Testing

https://www.atsjournals.org/doi/abs/10.1164/ajrccm.2025.211.Abstracts.A7881

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

**Tom Kindlon** @tomkindlon@disabled.social · May 3

May 3

Tom Kindlon @tomkindlon@disabled.social

"Therapist Perspective: Dan Wyke"

https://chroniclivingtherapy.com/dan-wyke-interview/

Comment: I liked this. I was going to share extracts but I think it's all good.

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@chronicillness
@spoonies
#counselling

Dan Wyke - a therapist's perspective

Dan Wyke (a person-centred counsellor from the South of England) reflects on his experiences as a therapist and person with MECFS.

He shares ideas and suggestions for both people with #MECFS and also therapists who work with them.

Amongst other things, I asked Dan 'what sort of things can you ask a therapist at an introductory meeting to reassure yourself about their level of understanding?'

read the interview with Dan Wyke

**Tom Kindlon** @tomkindlon@disabled.social · May 3

May 3

Tom Kindlon @tomkindlon@disabled.social

David Tuller's video interview with Andrew Ewing & David Joffe on Just-Published “Global Expert Consensus” on Long Covid, plus extract from associated press release

https://virology.ws/2025/05/02/trial-by-error-andrew-ewing-david-joffe-on-just-published-global-expert-consensus-on-long-covid/

Trial By Error: Andrew Ewing & David Joffe on Just-Published “Global Expert Consensus” on Long Covid
1 Comment / By David Tuller / 2 May 2025

By David Tuller, DrPH

*This is a crowdfunding period at University of California, Berkeley. If you appreciate my work and would like to make a donation (tax-deductible to US taxpayers) to the university in support of my position, here’s the link: https://crowdfund.berkeley.edu/project/46120

Last week, the journal Annals of Clinical Microbiology and Antimicrobials published the results of a major effort to collate international expertise on Long Covid. The article–“Long COVID clinical evaluation, research and impact on society: a global expert consensus”—was produced under the auspices of the Long COVID Advisory Group of the World Health Network, a global collaborative.

Earlier today, I spoke with Andrew Ewing, the document’s lead and corresponding author and a professor of chemistry and microbiology at the University of Gothenburg, Sweden, and David Joffe, a co-author and a respiratory and sleep physician in Sydney, Australia. Below, I have posted information from the World Health Network’s press release, which calls the situation “a wake-up call for governments and health systems,” followed by the interview.

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