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#thermophile

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Potassium
A very colorful hotspring near the Grand Prismatic Spring in Yellowstone Nationalpark. The colors result from dispersed silica (blue/green) which refract the sunlight. The warmer colors are small organisms (thermophiles) which live in hot springs and are colorful to absorb the sunlight. From those thermophiles the first enzymes for RNA/DNA analysis have been found. Also this was the cornerstone to our COVID vaccines today.

#landscape #landscapephotography #nikon #nikonphotography #nikond7500 #naturephotos #naturephotography #nature #pictureoftheday #potd #USA #northamerica
#yellowstone #yellowstonenp #wyoming #yellowstonenationalpark #nationalpark #hotspring #grandprismatic #thermophile #thermophilia #thermophilebacteria
#thermophilebacteria
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Joanna Masel

Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. biorxiv.org/content/10.1101/20. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper

bioRxivThe effectiveness of selection in a species affects the direction of amino acid frequency evolutionNearly neutral theory predicts that the effectiveness of natural selection will vary with species’ neutral genetic diversity, or effective population size ( N e ). This relationship allows comparisons among species with different effective population sizes to reveal subtle selective preferences for a variety of traits. We investigate one such trait – amino acid composition – and find that the efficacy of selection, measured as the Codon Adaptation Index of Species (CAIS), can predict amino acid frequencies across vertebrates. In addition to amino acid frequency (an evolutionary outcome), we also measure amino acid flux (an evolutionary process) on the branches separating mouse and rat, and compare it to flux on the branches separating human and chimpanzee. We decompose flux into a shared component that reflects a variety of universal artifacts, and a species-specific component capturing any effects of N e . The shared component of flux is correlated with structural disorder propensity. The species component is correlated with selective preference as measured by CAIS, i.e., the two methods agree on which amino acids are preferred under more effective selection, with the CAIS method providing higher statistical resolution, and producing a correlation with random peptide fitness effects. Within highly exchangeable pairs of amino acids, arginine is strongly preferred over lysine, and valine over isoleucine. Interestingly, these preferences match how thermophiles tend to differ from mesophilic relatives, as expected from theories of marginal protein stability at mutation-selection-drift balance. ### Competing Interest Statement The authors have declared no competing interest.
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